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Age and Calcium Metabolism in Relation to Cardiovascular Changes Induced by Renal Injury with Sodium Sulfaacetylthiazole
Author(s) -
Okano Kazutoshi,
Fujita Takuo,
Orimo Hajime,
Yoshikawa Masaki
Publication year - 1970
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1970.tb01330.x
Subject(s) - medicine , endocrinology , calcium , aorta , calcification , parathyroidectomy , kidney , parathyroid hormone , calcium metabolism
A bstract Obstructive nephropathy caused by a single intraperitoneal injection of sodium sulfaacetylthiazole (SAT) in a dosage of 0.5 gm/kg body weight induced interstitial myocarditis and medial calcification with medionecrosis of the aorta in 4‐month‐old rats but not in immature 1‐month‐old rats. The calcium content of the aorta, heart and kidneys and the 24‐hour uptake of 45 Ca by the aorta, heart and kidneys were significantly increased. The histological changes, the increased calcium content of the heart and aorta, and the increased uptake of 45 Ca were prevented by prior parathyroidectomy. Intraosseous 45 Ca two weeks after administration for the purpose of labelling the stable bone fraction, was markedly decreased by injection of SAT in rats above the age of 4 months with intact parathyroids but not in immature rats and in parathyroidectomized adult animals. Such mobilization of 45 Ca in the stable bone fraction was probably promoted through the increased secretion of parathyroid hormone secondary to SAT‐induced acute renal failure.