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ON THE PATHOGENESIS OF GASTRIC ULCER IN THE AGED AND ON THE ANTAGONISM BETWEEN CALCIFIED ATHEROSCLEROSIS AND GASTRIC CARCINOMA: A RADIOLOGICAL STUDY
Author(s) -
Elkeles Arthur
Publication year - 1970
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1970.tb01329.x
Subject(s) - medicine , atheroma , gastroenterology , pathogenesis , stomach , abdominal aorta , duodenum , aorta , carcinoma , cancer , pathology
A bstract Radiography of the abdominal aorta was used to study the incidence of calcified atheroma in 330 cases of primary gastric ulcer, 224 cases of gastric carcinoma, and 1,704 control cases. It is emphasized that the solitary gastric ulcer in the aged differs in its pathogenesis from gastric ulcers which are associated with lesions in the pyloric antrum or in the duodenum. Apparently classical gastric ulcer in patients over 50 years of age is a complication of atherosclerosis. “Calcified” atheroma in the abdominal aorta is relatively rare in gastric carcinoma even in the high age groups. The role of calcium in the stability of chromosomes, and the possible clinical applications are discussed. The concept is advanced that, when ageing is associated with increased affinity of the tissues for calcium, it leads to calcified atherosclerosis and relative immunity to cancer.