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ANTICOAGULANT THERAPY AS A POTENTIALLY EFFECTIVE METHOD FOR THE PREVENTION OF PRESENILE DEMENTIA: TWO CASE REPORTS
Author(s) -
WALSH ARTHUR C.
Publication year - 1968
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1968.tb02829.x
Subject(s) - medicine , dementia , etiology , anticoagulant therapy , intensive care medicine , blood supply , anticoagulant , pediatrics , surgery , disease
The hypothesis is proposed that presenile dementia results from arterial insufficiency of the brain consequent to a thrombotic process in the arteries supplying the brain. In accord with this hypothesis is the observation that in 9 patients, long‐term anticoagulant therapy appeared to prevent the expected progression of the dementia. Two illustrative case histories are given in detail. It is suggested that further therapeutic trials are warranted. It is also suggested that a thorough investigation of both the intracranial and extracranial arterial blood supply to the brain in patients with presenile dementia might yield useful information as to the etiology.