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COMPARISON OF THE EFFICACY AND SIDE EFFECTS OF TWO SYMPATHOMIMETIC AMINE BRONCHODILATOR AEROSOLS: A STUDY OF REPETITIVE DOSING *
Author(s) -
Cohen Burton Marcus
Publication year - 1968
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1968.tb02763.x
Subject(s) - medicine , phenylephrine , bronchodilator , anesthesia , dosing , heart rate , blood pressure , bronchodilator agents , placebo , isoprenaline , cardiology , asthma , stimulation , alternative medicine , pathology
A bstract A comparison of two sympathomimetic amine bronchodilator aerosols was made in 10 adult patients with chronic obstructive respiratory disease. Isoproterenol, an isoproterenol‐phenylephrine combination and placebo were administered in a sequence of pairs (double‐blind pattern) at the rate of 6 inhalations at five‐minute intervals; this procedure was repeated on three successive days. Isoproterenol‐phenylephrine was more effective than isoproterenol alone, as shown by pulmonary function tests. It seemed to prevent augmentation of the cardiovascular effects of isoproterenol. Isoproterenol‐phenylephrine had about the same effect as proterenol with regard to acceleration of the heart rate, rise in systolic blood pressure, and the production of tremulousness. Repetitive dosing with these aerosols (strictly limited to the rates and amounts described) results in step‐like improvement in expiratory airflow defects, and side reactions are minimal.