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Interactions Between the Apolipoprotein A 1/ C 3/ A 5 Haplotypes and Alcohol Consumption on
Serum Lipid Levels
Author(s) -
Yin RuiXing,
Li YiYang,
Wu JinZhen,
Pan ShangLing,
Liu ChengWu,
Lin WeiXiong,
Yang DeZhai
Publication year - 2013
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2012.01918.x
Subject(s) - haplotype , apolipoprotein b , genotype , allele , alcohol consumption , genotyping , alcohol , medicine , chemistry , biology , endocrinology , microbiology and biotechnology , cholesterol , genetics , biochemistry , gene
Background The interactions between apolipoprotein ( A po) A 1/ C 3/ A 5 haplotypes and alcohol consumption on serum lipid profiles have not been previously explored. The present study was undertaken to detect the polymorphisms of A po A 1 −75 bp G > A (rs1799837), A po C 3 3238 C > G (rs5128), A po A 5 −1131 T > C (rs662799), A po A 5 c.553 G > T (rs2075291), and A po A 5 c.457 G > A (rs3135507) and the interactions between their haplotypes and alcohol consumption on serum lipid levels. Methods Genotyping was performed in 1,030 unrelated subjects (516 nondrinkers and 514 drinkers) aged 15 to 89. The interactions between A po A 1/ C 3/ A 5 haplotypes and alcohol consumption on serum lipid levels were detected by factorial regression analysis after controlling for potential confounders. Results The frequencies of A po C 3 3238 CG / GG genotypes and A po A 1 −75 bp A allele in nondrinkers were higher in females than in males ( p < 0.05). The frequencies of A po C 3 3238 CG / GG genotypes and G allele in drinkers were higher in females than in males ( p < 0.05). The frequencies of A po A 1 −75 bp GA / AA genotypes and A allele in males were higher, and those of A po C 3 3238 CG / GG genotypes were lower in drinkers than in nondrinkers ( p < 0.05 to 0.01). The frequency of A po C 3 3238 GG genotype in male drinkers was also higher in ≥25 g/d than in <25 g/d subgroups ( p < 0.05). There were 11 haplotypes with a frequency >1% in our study population. The haplotypes of G – G – T – C – G (in the order of c.553 G > T , c.457 G > A , −1131 T > C , 3238 C > G , and −75 bp G > A ), G – G – T – C – A , and G – G – C – G – G were shown consistent interactions with alcohol consumption to increase serum total cholesterol, high‐density lipoprotein cholesterol ( HDL ‐ C ), and ApoA1 levels ( p < 0.05 to 0.001). The interactions between G – G – T – G – G ( HDL ‐ C and A po A 1), G – G – C – C – A ( A po A 1), G – A – T – C – G (triglyceride), G – G – T – C – G ( A po A 1/ A po B ratio), and G – G – C – G – G ( A po B ) haplotypes and alcohol consumption on serum lipid levels were also detected ( p < 0.05 to 0.001); the levels of these serum lipid parameters were significantly higher in drinkers than in nondrinkers. Conclusions The differences in serum lipid parameters between drinkers and nondrinkers might partly result from different interactions between the A po A 1/ C 3/ A 5 haplotypes and alcohol consumption.