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Possible Association Between OPRM 1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms
Author(s) -
Koller Gabriele,
Zill Peter,
Rujescu Dan,
Ridinger Monika,
Pogarell Oliver,
Fehr Christoph,
Wodarz Norbert,
Bondy Brigitta,
Soyka Michael,
Preuss Ulrich W.
Publication year - 2012
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2011.01714.x
Subject(s) - alcohol dependence , alcohol , opioid , locus (genetics) , analysis of variance , opioid receptor , medicine , polymorphism (computer science) , association (psychology) , genotype , genetics , receptor , psychology , biology , gene , biochemistry , psychotherapist
Background Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence ( AD ) risk. Conflicting results were reported on the role of the mu‐opioid receptor ( OPRM 1) polymorphism A 118 G ( A sn40Asp, rs1799971) in the development of alcoholism. Methods We investigated a total number of 1,845 alcohol‐dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu‐opioid receptor ( OPRM 1) polymorphism using chi‐square statistics. Results An association between the OPRM variant and AD was detected ( p = 0.022), in recessive ( AA vs. GA / GG ) and co‐dominant ( AA vs. GA ) models of inheritance. An association between the OPRM variant and the DSM ‐ IV criterion “efforts to cut down or could not” ( p = 0.047) was found, but this did not remain significant after the correction for multiple testing. Conclusions The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD , although the association is only nominally significant.