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Dendritic Cells in Alcoholic Liver Injury and Fibrosis
Author(s) -
Aloman Costica,
Friedman Scott L.,
Merad Miriam
Publication year - 2011
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2010.01397.x
Subject(s) - immune system , acquired immune system , dendritic cell , immunology , antigen presentation , haematopoiesis , liver injury , innate immune system , mechanism (biology) , function (biology) , population , biology , medicine , microbiology and biotechnology , t cell , stem cell , endocrinology , philosophy , environmental health , epistemology
Alcohol consumption impairs the development of innate and adaptive immune responses, however the exact mechanism by which alcohol leads to immune defects remains to be established. Dendritic cells (DCs) form a heterogeneous population of hematopoietic cells that are present in all tissues including the liver. DC are initially described playing a key role in the induction of innate and adaptive immune response against specific antigens. In our presentation, we discussed few new aspects of DC development, critical assessment of DC in non‐lymphoid organs and the impact of alcohol consumption on DC function. Understanding the mechanism by which DC modulate liver function after alcohol consumption may help uncover novel therapeutic strategies for the treatment of these conditions.