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Functional Imaging of Cognitive Control During Acute Alcohol Intoxication
Author(s) -
Anderson Beth M.,
Stevens Michael C.,
Meda Shashwath A.,
Jordan Kathryn,
Calhoun Vince D.,
Pearlson Godfrey D.
Publication year - 2011
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2010.01332.x
Subject(s) - functional magnetic resonance imaging , insula , alcohol , prefrontal cortex , alcohol intoxication , cingulate cortex , brain activity and meditation , cognition , anterior cingulate cortex , parietal lobe , neuroscience , psychology , functional imaging , error related negativity , medicine , poison control , electroencephalography , central nervous system , injury prevention , biology , biochemistry , environmental health
Background: The anterior cingulate and several other prefrontal and parietal brain regions are implicated in error processing and cognitive control. The effects of different doses of alcohol on activity within these brain regions during a functional magnetic resonance imaging (fMRI) task where errors are frequently committed have not been fully explored. Methods: This study examined the impact of a placebo [breath alcohol concentration (BrAC) = 0.00%], moderate (BrAC = 0.05%), and high (BrAC = 0.10%) doses of alcohol on brain hemodynamic activity during a functional MRI (fMRI) Go/No‐Go task in 38 healthy volunteers. Results: Alcohol increased reaction time and false alarm errors in a dose‐dependent manner. fMRI analyses showed alcohol decreased activity in anterior cingulate, lateral prefrontal cortex, insula, and parietal lobe regions during false alarm responses to No‐Go stimuli. Conclusions: These findings indicate that brain regions implicated in error processing are affected by alcohol and might provide a neural basis for alcohol’s effects on behavioral performance.