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Influence of Dissolved Oxygen Concentration on the Pharmacokinetics of Alcohol in Humans
Author(s) -
Baek Inhwan,
Lee Byungyo,
Kwon Kwangil
Publication year - 2010
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2010.01155.x
Subject(s) - alcohol , oxygen , chemistry , ethanol , pharmacokinetics , oxidizing agent , limiting oxygen concentration , metabolism , chromatography , biochemistry , pharmacology , organic chemistry , medicine
Background: Ethanol oxidation by the microsomal ethanol oxidizing system requires oxygen for alcohol metabolism, and a higher oxygen uptake increases the rate of ethanol oxidation. We investigated the effect of dissolved oxygen on the pharmacokinetics of alcohol in healthy humans ( n = 49). The concentrations of dissolved oxygen were 8, 20, and 25 ppm in alcoholic drinks of 240 and 360 ml (19.5% v/v). Methods: Blood alcohol concentrations (BACs) were determined by converting breath alcohol concentrations. Breath samples were collected every 30 min when the BAC was higher than 0.015%, 20 min at BAC ≤0.015%, 10 min at BAC ≤0.010%, and 5 min at BAC ≤0.006%. Results: The high dissolved oxygen groups (20, 25 ppm) descended to 0.000% and 0.050% BAC faster than the normal dissolved oxygen groups (8 ppm; p < 0.05). In analyzing pharmacokinetic parameters, AUC inf and K el of the high oxygen groups were lower than in the normal oxygen group, while C max and T max were not significantly affected. In a Monte Carlo simulation, the lognormal distribution of mean values of AUC inf and t 1/2 was expected to be reduced in the high oxygen group compared to the normal oxygen group. Conclusions: In conclusion, elevated dissolved oxygen concentrations in alcoholic drinks accelerate the metabolism and elimination of alcohol. Thus, enhanced dissolved oxygen concentrations in alcohol may have a role to play in reducing alcohol‐related side effects and accidents.