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The Relationship Between Serotonin Receptor 1B Polymorphisms A‐161T and Alcohol Dependence
Author(s) -
Lee ShengYu,
Lin WeiWen,
Huang SanYuan,
Kuo PoHsiu,
Wang ChenLin,
Wu PeiLin,
Chen ShiouLan,
Wu Jo YungWei,
Ko HueiChen,
Lu RuBand
Publication year - 2009
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2009.00990.x
Subject(s) - genotype , allele , polymorphism (computer science) , medicine , anxiety , alcohol dependence , depression (economics) , psychiatry , gene , genetics , alcohol , biology , biochemistry , macroeconomics , economics
Background: Several studies have suggested that the serotonin receptor 1B gene ( 5HT1B ) may be important in the pathogenesis of alcohol dependence (alcoholism; ALC; AD). We examined whether 5HT1B gene A‐161T polymorphisms (rs130058) are a susceptibility factor for total AD and subgroups of AD. We further explored correlation of this 5HT1B gene variant between anxiety–depression alcoholism (ANX/DEP ALC) and antisocial alcoholism (antisocial ALC) subgroups because of the high comorbidity of anxiety–depression, antisocial personality disorder, and AD. Methods: We recruited 522 Han Chinese in Taiwan for this study: 322 AD patients and 200 controls. The patient group was recruited primarily from medical teaching hospitals; patients with antisocial alcoholism were recruited from Taiwanese prisons. Individuals with AD were classified into 3 homogeneous clinical subgroups—pure alcoholism (pure ALC), ANX/DEP ALC, and antisocial ALC—using DSM‐IV diagnosis. The 5HT1B gene A‐161T polymorphism was determined using PCR–RFLP. Results: No significant differences in genotypic and allelic frequencies were found between controls and the total AD group or between controls and the 3 AD subgroups. However, there were significant differences in the 5HT 1B gene A‐161T polymorphism at both the genotype and allelic levels between the ANX/DEP ALC and antisocial ALC subgroups. Conclusions: This study suggests that the 5HT1B gene A‐161T polymorphism alone is not a risk factor for increasing susceptibility to either AD or its subtypes. However, 5HT1B gene A‐161T polymorphisms might be one of the common genetic factors between the ANX/DEP ALC and antisocial ALC subgroups.