Premium
Predictive Factors for Pure Steatosis in Alcoholic Patients
Author(s) -
Naveau Sylvie,
Thaury Juliette,
BarriOva Nadège,
Balian Axel,
Dauvois Barbara,
NjikéNakseu Micheline,
Prévot Sophie,
Agostini Hélène,
Perlemuter Gabriel
Publication year - 2009
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2009.00932.x
Subject(s) - steatosis , medicine , fatty liver , body mass index , metabolic syndrome , odds ratio , gastroenterology , endocrinology , waist , blood pressure , obesity , disease
Background: Bearing in mind the mechanisms involved in nonalcoholic fatty liver disease, this study aims to verify whether metabolic syndrome or its various individual components are independent predictive factors for steatosis ≥10% in alcoholic patients. Methods: This study included 281 consecutive alcoholic patients with abnormal liver tests and either normal liver histology or steatosis <10% ( n = 119) or steatosis ≥10% ( n = 162). Logistic regression analysis was used to study the relationship between metabolic syndrome components and various risk factors and the presence of steatosis ≥10%. We assessed apolipoprotein A1 (ApoA‐1) levels, a major protein component of plasma high‐density lipoprotein (HDL), rather than HDL‐cholesterol levels. Results: Plasma ApoA‐1 levels ( p < 0.01), body mass index (BMI) ( p < 0.01), and waist circumference ( p < 0.05) were significantly higher in patients with steatosis ≥10% than in patients with normal liver histology or steatosis <10%. A higher percentage of patients with steatosis ≥10% had high blood pressure ( p = 0.003) than patients with normal liver histology or steatosis <10%. In the logistic regression, ApoA‐1 [odds ratio (OR) = 1.57 (1.10–2.22)], BMI [OR = 1.10 (1.01–1.23)], and high blood pressure [OR = 1.84 (1.10–3.06)] were positively and independently correlated with the presence of steatosis ≥10%. In the multivariate regression high blood pressure was independently and positively correlated with steatosis score ( r = 0.55 ± 0.26; p < 0.05). On the other hand, when the presence of high blood pressure was the dependent variable, the presence of steatosis ≥10% positively and independently correlated with it [OR = 1.82 (1.05–3.15)]. Conclusion: In alcoholic patients without fibrosis, ApoA‐1, BMI, and high blood pressure on the next morning after the admission were predictive of steatosis ≥10%. High blood pressure was the only metabolic syndrome component associated with the presence of alcoholic steatosis ≥10% and was not correlated with other metabolic syndrome components. These findings suggest that steatosis mechanisms are different in alcoholic and nonalcoholic fatty liver.