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Evaluation of Quantitative Portal Venous, Hepatic Arterial, and Total Hepatic Tissue Blood Flow Using Xenon CT in Alcoholic Liver Cirrhosis—Comparison With Liver Cirrhosis Related to Hepatitis C Virus and Nonalcoholic Steatohepatitis
Author(s) -
Takahashi Hideaki,
Suzuki Michihiro,
Ikeda Hiroki,
Kobayashi Minoru,
Sase Shigeru,
Yotsuyanagi Hiroshi,
Maeyama Shiro,
Iino Shiro,
Itoh Fumio
Publication year - 2010
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2008.00755.x
Subject(s) - cirrhosis , medicine , gastroenterology , steatohepatitis , alcoholic liver disease , alcoholic hepatitis , portal venous pressure , nonalcoholic steatohepatitis , fatty liver , portal hypertension , nonalcoholic fatty liver disease , disease
Background/Aims: Xenon computed tomography (Xe‐CT) is a noninvasive method of quantifying and visualizing tissue blood flow (TBF). For the liver, Xe‐CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe‐CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL‐LC), compared with liver cirrhosis related to nonalcoholic steatohepatitis (NASH), (NASH‐LC), and hepatitis C virus (HCV), (C‐LC). Methods: Xe‐CT was performed on 22 patients with AL‐LC, 7 patients with NASH‐LC, and 24 patients with C‐LC. Severity of LC was classified according to Child‐Pugh classification. Correlations between hepatic TBF, Child‐Pugh classification, and indocyanin green retention (ICG) rate after 15 minutes (ICG15R) were examined. Correlations of hepatic TBF in Child‐Pugh class A to AL‐LC, NASH‐LC, and C‐LC were also examined. Results: Portal venous TBF (PVTBF) displayed a significant negative correlation with Child‐Pugh score and ICG15R ( r = −0.432, p < 0.01, r = −0.442, p < 0.01, respectively). Moreover, ICG15R displayed a significant positive correlation with Child‐Pugh score ( r = 0.661, p < 0.001). Meanwhile, mean PVTBF and total hepatic TBF (THTBF) was significantly lower in AL‐LC than in C‐LC ( p < 0.05). Mean PVTBF was significantly lower in Child‐Pugh class A to AL‐LC and NASH‐LC than in that to C‐LC ( p < 0.05). Similarly, mean THTBF was significantly lower in Child‐Pugh class A to NASH‐LC than in that to C‐LC ( p < 0.05). Conclusions: Measurement of hepatic TBF using Xe‐CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.