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Analysis of Single Nucleotide Polymorphisms and Haplotypes in the Neuropeptide Y Gene: No Evidence for Association With Alcoholism in a German Population Sample
Author(s) -
Zill Peter,
Preuss Ulrich W.,
Koller Gabrielle,
Bondy Brigitta,
Soyka Michael
Publication year - 2008
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2007.00586.x
Subject(s) - haplotype , german , single nucleotide polymorphism , genetics , german population , sample (material) , association (psychology) , gene , population , biology , genetic association , psychology , genotype , medicine , chemistry , history , environmental health , chromatography , archaeology , psychotherapist
Background: Several lines of evidence from animal and electrophysiological studies indicate that the neuropeptide Y (NPY) gene is involved in the pathophysiology of alcohol dependence. Recent studies have provided evidence for an association between a Leu7Pro polymorphism, as well as 2 promoter single nucleotide polymorphisms (SNPs) in the NPY gene (G‐602T, T‐399C) and alcohol dependence. The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism. Methods: We performed single SNP and haplotype studies in 465 alcohol dependent patients and 448 healthy controls with 3 SNPs in the promoter region (−883ins/del, G‐602T, T‐399C) and the Leu7Pro polymorphism in exon 2 of the NPY gene. Results: Neither single SNP‐, nor haplotype analysis could detect significant associations with alcohol dependence. Additionally we could not detect any relation to Cloninger’s Type 1/2 or Babor’s Type A/B classification, to withdrawal symptoms, to the age of onset or to the amount of alcohol intake. Conclusions: In conclusion, our results suggest that the analyzed SNPs, as well as the corresponding haplotypes of the NPY gene are unlikely to play a major role in the pathophysiology of alcohol dependence in the investigated sample from the German population. Further analyses are needed to confirm the present results.