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Linkage Disequilibrium and Association Analysis of α ‐Synuclein and Alcohol and Drug Dependence in Two American Indian Populations
Author(s) -
Clarimon Jordi,
Gray Rebecca R.,
Williams Lindsey N.,
Enoch MaryAnne,
Robin Robert W.,
Albaugh Bernard,
Singleton Andrew,
Goldman David,
Mulligan Connie J.
Publication year - 2007
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2007.00338.x
Subject(s) - international hapmap project , linkage disequilibrium , single nucleotide polymorphism , genetics , biology , alcohol dependence , population , genetic association , haplotype , snp , allele , medicine , genotype , gene , alcohol , biochemistry , environmental health
Alpha-synuclein is involved in dopaminergic neurotransmission and has been implicated in a number of neurodegenerative disorders, such as Parkinson's disease. Recent studies, in humans and in rat and monkey models, have suggested that alpha-synuclein may play a role in the development and maintenance of certain addictive disorders.