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Efficacy of Nicotine Patch in Smokers With a History of Alcoholism
Author(s) -
Hughes John R.,
Novy Pamela,
Hatsukami Dorothy K.,
Jensen Joni,
Callas Peter W.
Publication year - 2003
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2003.tb04419.x
Subject(s) - abstinence , sobriety , nicotine , odds ratio , smoking cessation , medicine , placebo , craving , alcohol dependence , nicotine patch , nicotine replacement therapy , alcohol , smoking history , family history , nicotine withdrawal , odds , psychiatry , addiction , logistic regression , biochemistry , chemistry , alternative medicine , pathology
Background: Smokers with a history of alcohol dependence may have more difficulty quitting, might relapse to alcohol use, and might especially benefit from nicotine replacement therapy for smoking cessation. Methods: One hundred fifteen smokers with a history of alcohol dependence (median of 5 years previously) were randomly assigned to either a 21‐mg nicotine patch or placebo in a trial designed to be as similar as possible to a prior study that examined smokers with no history of alcoholism. Both studies were of heavy smokers with similar levels of nicotine dependence; thus, any differences in trials would be due to a history of alcohol problems per se. Results: In the current trial, adjusted prolonged smoking abstinence in those with a history of alcohol dependence was higher in the active than the placebo group at end‐of‐treatment (28% vs. 11%; odds ratio, 3.2; p = 0.04) and at 6‐month follow‐up (24% vs. 6%; odds ratio, 4.9; p = 0.02). Among subjects not lost to follow‐up, none reported drinking problems or increases in craving for alcohol. Smoking abstinence was not lower and the odds ratio for nicotine patch therapy was not greater in smokers with a history of alcohol dependence than in smokers with no such history. Conclusions: Heavy smokers with a history of alcoholism benefit from nicotine patch treatment. A history of alcohol problems after a period of stable sobriety does not appear to influence smoking outcomes or response to nicotine replacement. Although no smokers relapsed to alcohol use, a trial that follows up all subjects is needed to verify this.