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Significant Correlation Between Insulin Resistance and Serum Gamma‐Glutamyl Transpeptidase (γ‐GTP) Activity in Non‐Drinkers
Author(s) -
Yokoyama Hirokazu,
Hirose Hiroshi,
Moriya Susumu,
Saito Ikuo
Publication year - 2002
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2002.tb02710.x
Subject(s) - medicine , insulin resistance , gtp' , triglyceride , endocrinology , body mass index , uric acid , insulin , cholesterol , alanine aminotransferase , alanine transaminase , chemistry , enzyme , biochemistry
To understand the significance of elevated serum γ‐GTP levels, factors relevant to the serum γ‐GTP level were studied using data of health check‐ups for the employees of a Japanese corporation. The γ‐GTP level was positively correlated with levels of various liver function tests including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Except for them, the γ‐GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index. The correlation between the γ‐GTP level and LDL cholesterol was also observed only when subjects who drank more than 5 times a week were selectively studied. When non‐drinkers and opportunity drinkers were selectively studied, 63.6% of subjects whose γ‐GTP level was more than 120 IU/liter showed elevated insulin resistance levels. Multiple factors including insulin resistance may affect serum γ‐GTP activity in clinical subjects.