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Moderate Alcohol Consumption and Postprandial Plasma Lipids in Men With Different Risks for Coronary Heart Disease
Author(s) -
Hendriks Henk F.J.,
Haaren Marian R.T.,
Leenen Rianne,
Schaafsma Gertjan
Publication year - 2001
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2001.tb02251.x
Subject(s) - postprandial , alcohol , medicine , body mass index , cholesterol , triglyceride , abstinence , endocrinology , blood lipids , physiology , chemistry , biochemistry , insulin , psychiatry
Background: Moderate alcohol consumption is associated with a reduced coronary heart disease (CHD) risk. Epidemiologic studies have provided conflicting data which suggests that CHD protection may be modulated or may not be modulated by a person's CHD risk profile. Methods: We examined the effects of moderate alcohol consumption (35 g/day) on postprandial lipoprotein metabolism in two groups of healthy middle‐aged men who had different plasma total cholesterol, triglyceride concentrations, and body mass index (BMI), which are three major risk factors for CHD; 11 men had lower plasma lipids and BMI (L‐men) and 11 men had higher plasma lipids and BMI (H‐men). The effects of alcohol on postprandial lipoprotein metabolism were studied in a crossover design after an acute moderate alcohol intake both after a period of abstinence (alcohol‐free beer) and after a period of moderate alcohol consumption (alcohol containing beer). Results: Moderate alcohol consumption changed plasma total cholesterol, total triglycerides, and HDL composition in the postprandial period. Alcohol‐induced changes were essentially the same over time in both L‐men and H‐men. However, changes occurred at a different overall plasma concentration for total cholesterol and total triglycerides. Also, the postprandial response to an acute moderate alcohol dose after a period of abstinence seemed not to essentially differ from the response to an acute moderate alcohol dose after a 4‐week period of moderate alcohol consumption. Conclusions: These results suggest that men who differ in risk for CHD, based on plasma lipids and BMI, but without previous or underlying disease, have a similar postprandial lipid response to a moderate dose of alcohol.