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Dopamine D2 Receptor Gene ( DRD2 ) Is Associated With Alcoholism With Conduct Disorder
Author(s) -
Lu RuBand,
Lee JiaFu,
Ko HueiChen,
Lin WeiWen
Publication year - 2001
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2001.tb02196.x
Subject(s) - conduct disorder , haplotype , dopamine receptor d2 , psychology , gambling disorder , psychiatry , allele , bipolar disorder , alcohol use disorder , medicine , dopamine , addiction , genetics , gene , alcohol , biology , neuroscience , mood , biochemistry
This study examined whether there is evidence for an association between alcoholism with conduct disorder and alleles of the Taq I A and Taq I B polymorphisms, both individually and as haplotypes, at the dopamine D2 receptor gene ( DRD2 ). We studied 182 Han Chinese subjects, including 34 alcoholics with conduct disorder, 63 alcoholics without conduct disorder, and 85 nonalcoholics. Alcohol dependence and conduct disorder were defined according to DSM‐III‐R criteria. Significant associations were observed between Taq I A and Taq I B at the DRD2 locus, tested individually and as haplotypes, and alcoholism with conduct disorder. Our results suggested that DRD2 might be associated with conduct disorder or a predisposition to both conduct disorder and alcoholism. However, this needs to be further investigated by examining the differences among conduct disorder with alcoholism, conduct disorder only, and controls for the Taq I A and B system at DRD2 .