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An Association Study Between Alcoholism and the Serotonergic Receptor Genes
Author(s) -
Himei Akio,
Kono Yoshihiro,
Yoneda Hiroshi,
Sakai Toshiaki,
Koh Jun,
Sakai Jun,
Inada Yasushi,
Imamichi Hiroyuki
Publication year - 2000
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2000.tb04618.x
Subject(s) - serotonergic , association (psychology) , gene , medicine , psychology , receptor , genetics , biology , serotonin , psychotherapist
Background: Linkage and association studies of alcoholism using DNA makers have been conducted without conclusive results. The comorbidity of alcoholism with affective disorder indicates that dysfunction of the serotonergic system may play an important role in developing alcoholism. Methods: We studied the genetic association between alcoholism and alleles of the HTR1A, HTR2A , and HTR2C genes. The subjects were 91 biologically unrelated alcoholics and 90 controls. Polymorphisms of these genes were determined by polymerase chain reaction restriction fragment length polymorphisms, and the data were analyzed by X 2 tests. Results: We found no significant association between alcoholism and the HTR1A, HTR2A , and HTR2C genes. Conclusions: The study results suggest that these serotonergic receptor genes may not directly contribute to the etiology of alcoholism.