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A Study of Colloidal Scintigraphy in Alcoholic Liver Diseases: Discordance from Asialo‐Scintigraphic Findings
Author(s) -
Koreeda Chizu,
Kawa Sang Kil Ha,
Takasu Masahi,
Satoh Masahiro,
Takemoto Hiroto,
Mizuno Takako,
Sawada Satoshi,
Inoue Kyouichi
Publication year - 2000
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.2000.tb00011.x
Subject(s) - scintigraphy , alcoholic liver disease , medicine , gastroenterology , liver function tests , liver parenchyma , liver function , nuclear medicine , cirrhosis
Background: Our study was undertaken to check the discordance between findings from 99m Tc‐Sn colloidal reticuloendothelial scintigraphy (RESS) and 99m Tc‐GSA asialo‐scintigraphy (GSA, a technique for evaluation of liver parenchymal cell density and function) and to analyze the discordance in relation to functional disturbances. We compared data between patients with alcoholic liver diseases (ALD) and patients with viral liver diseases (VLD). Methods: The subjects of this study were 40 patients with chronic liver disease (17 with ALD and 23 with VLD). We used the liver uptake ratio of the tracer of the Sn colloid (SnL 15 , %), the liver uptake rate (GSAL 15 , %), and the Rmax (an indicator of total liver receptors) as indices of liver scans. Results: GSAL 15 was sometimes nondiscordant from SnL 15 . The patients were divided into two groups: the nondiscordant group (26 cases where the balance/sum of the two variables was <25%) and the discordant group (14 cases where the balance/sum was >25%). SnL 15 was 41.6 ± 16.2% in the nondiscordant group and 42.7 ± 16.3% in the discordant group ( p = 0.80). GSAL 15 was 34.3 ± 12.1% in the nondiscordant group and 21.5 ± 8.1% in the discordant group ( p = 0.001). Rmax was 0.33 ± 0.17 in the nondiscordant group and 0.113 ± 0.008 in the discordant group (p = 0.002). Thus, the SnL 15 , as determined by RESS, did not differ significantly between the nondiscordant and discordant groups, whereas GSAL 15 was significantly unfavorable in the discordant group as compared with the nondiscordant group. SnL 15 as determined by RESS did not differ significantly between the ALD group (40.4 ± 18.7%) and the VLD group (43.5 ± 15.0%) ( p = 0.59), whereas Rmax as determined by GSA was significantly improved in the ALD group (0.34 ± 0.20) compared with the VLD group (0.20 ± 0.4) ( p = 0.02). Conclusions: Liver cell function was lower in cases that showed discordance between liver cell function and reticuloendothelial function compared with cases without such discordance, although reticuloendothelial function did not differ between discordant and nondiscordant groups. Liver cell function was better in cases of ALD than in cases of VLD, whereas reticuloendothelial function did not differ between the ALD group and the VLD group.