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Acetaldehyde‐Mediated Collagen Regulation in Hepatic Stellate Cells
Author(s) -
Greenwel Patricia
Publication year - 1999
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1999.tb04206.x
Subject(s) - hepatic stellate cell , acetaldehyde , extracellular matrix , downregulation and upregulation , metabolite , cirrhosis , chemistry , ethanol , microbiology and biotechnology , biochemistry , biology , endocrinology , medicine , gene
Alcohol‐induced liver cirrhosis is one of the major causes of death worldwide. Strong evidence has established that ethanol's first metabolite, acetaldehyde, is highly fibrogenic and enhances the deposition of many extracellular matrix components by hepatic stellate cells. This article reviews our current knowledge of the molecular mechanisms whereby acetaldehyde induces these activities, with particular emphasis on those related to the upregulation of type I collagen.