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Ethanol Feeding Does Not Affect the Efficacy or Pharmacokinetics of Azithromycin, Trovafloxacin, or Ceftriaxone in a Rat Model of Pneumococcal Pneumonia
Author(s) -
Preheirn Laurel C.,
Olsen Keith M.,
Yue Mei,
Snitily Mary U.,
Gentry Martha J.
Publication year - 1999
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1999.tb04192.x
Subject(s) - trovafloxacin , ceftriaxone , azithromycin , streptococcus pneumoniae , pneumonia , medicine , pneumococcal pneumonia , pharmacokinetics , microbiology and biotechnology , antibiotics , pharmacology , biology
A rat model of ethanol feeding was used to study the effects of ethanol on antibiotic therapy of pneumococcal pneumonia. Male Sprague‐Dawley rats (150 g) received a liquid diet containing 36% of total calories as ethanol. Controls were pair‐fed a liquid diet without ethanol or received rat chow. Diets began 7 days pre‐ and continued postinfection. Rats were infected transtracheally with type 3 Streptococcus pneumoniae and then treated with azithromycin (50 mg/kg), trovafloxacin (50 mg/kg), or ceftriaxone (100 mg/kg) injected subcutaneously twice daily for 5 days. Antibiotic levels in serum, lung cells, and lavage fluid were measured by HPLC. Ethanol‐ and pair‐fed rats had depressed baseline peripheral neutrophil counts hut were able to generate adequate numbers of peripheral and pulmonary polymorphonuclear leukocytes early in the course of their infection. Ethanol feeding did not alter the pharmacokinetics of azithromycin, trovafloxacin, or ceftriaxone. All three antibiotics were equally effective in curing experimental pneumococcal pneumonia, and survival rates were similar in treated ethanol‐fed and control rats.