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Allele Dose Analysis in Recombinant Inbred Strains: A Tool for Multiple Phenotype Analysis With Implications for Quantitative Trait Loci Mapping
Author(s) -
Markel P. D.,
Erwin V. G.
Publication year - 1999
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1999.tb04161.x
Subject(s) - quantitative trait locus , biology , trait , phenotype , allele , recombinant dna , genetics , genetic analysis , inbred strain , computational biology , gene , computer science , programming language
A considerable investment in genetic mapping is necessary to confirm linkages of quantitative trait loci for complex traits such as ethanol sensitivity, a significant predictor of alcoholism. Before embarking on such intensive mapping efforts in large intercrosses, we suggest an approach based on genetic marker data in recombinant strains that yield a rationale for selecting a battery of related phenotypes for confirmation studies of quantitative trait loci action. Using this approach with selected strains of mice, we retrospectively consider the relationship between ethanol sensitivity and neurotensin levels in several mammalian brain regions.