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Bone Age and Growth in Fetal Alcohol Syndrome
Author(s) -
Habbick Brian F.,
Blakley Patricia M.,
Houston C. Stuart,
Snyder Richard E.,
Senthilselvan A.,
Nanson J. L.
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1998.tb03913.x
Subject(s) - medicine , head circumference , bone age , fetal alcohol syndrome , short stature , pediatrics , fetus , birth weight , pregnancy , biology , genetics
We have found delayed mean bone age in 63 children with fetal alcohol syndrome (FAS). The mean bone age Z‐score for boys ( n = 31) was −2.12 SDs and for girls ( n = 32) was ‐1.62 SDs. This might suggest that they have potential for catch‐up growth. However, experience with children with intrauterine growth retardation suggests that this will not be the case and that FAS children will be of reduced height at maturity. Further support for this assumption was gained from a sample of 26 patients who were followed until at least the age of 14 years for females and 16 years for males. There was no significant change in height Z‐scores from early childhood to early adulthood, the mean score being ‐2.16 SDs and ‐2.11 SDs at mean ages of 4.83 years and 18.69 years, respectively. On the other hand, there were significant changes in weight and head circumference. The mean weight Z‐score changed from ‐2.10 SDs to ‐1.14 SDs ( p < 0.001). The head circumference mean Z‐score in 16 patients was ‐3.13 SDs at a mean age of 2.79 years and ‐2.63 SDs at a mean age of 17.37 years ( p = 0.013). Short stature can continue to be used as a diagnostic criterion for FAS beyond childhood.