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Effects of Nicotine and Mecamylamine Microinjections into the Nucleus Accumbens on Ethanol and Sucrose Self‐Administration
Author(s) -
Nadal R.,
Chappell A. M.,
Samson H. H.
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1998.tb03898.x
Subject(s) - mecamylamine , nucleus accumbens , self administration , nicotinic agonist , nicotine , pharmacology , microinjection , antagonist , chemistry , agonist , microinjections , nicotinic antagonist , anesthesia , dopamine , endocrinology , medicine , receptor , biochemistry
Nicotine (NIC) and ethanol (ETOH) are both drugs of abuse that can affect similar pathways in the central nervous system. However, the role of nicotinic processes in ETOH's reinforcing actions is unclear. Although the mesolimbic dopamine systems are known to be involved in the reinforcing effects of ETOH, the role of nicotinic receptors within the nucleus accumbens (NAc) in ETOH reinforcement has not been studied. To address this issue, adult male Long‐Evans rats were initiated to self‐administer ETOH (l0% v/v, n = 14) using the sucrose‐substitution procedure or sucrose (5% w/v, n = 8) in a 30‐min operant session. They were then surgically implanted with bilateral stainless‐steel guide cannulae to allow for microinjection into the core of the NAc. After recovery from surgery, presession micro‐injections of NIC (0.3, 3.3, 10, 30, and 60 μg/1 μ1/brain) or the antagonist mecamylamine (MEC) (1, 3, 10, 30, and 60 μg/1 μl/brain) were performed prior to an ETOH or sucrose self‐administration session. NIC (3.3 and 60 μg/μl) and MEC (30 μg/μl) both reduced ETOH self‐administration behavior, without affecting sucrose‐reinforced behavior. A reduction in the total duration of ETOH responding (termination) was also observed after either 60 μg/μl of NIC and 30 μg/μl of MEC. The lack of a clear dose‐response relationship for the agonist and the antagonist indicates that the interaction between the NAc nicotinic system and ETOH self‐administration is complex.