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Association Study Between the 441C Ins/Del and TaqI A Polymorphisms of the Dopamine D2 Receptor Gene and Alcoholism
Author(s) -
Ishiguro Hiroki,
Arinami Tadao,
Saito Toshikazu,
Akazawa Shigeru,
Enomoto Minoru,
Mitushio Hiroshi,
Fujishiro Hiroshi,
Tada Kunimaro,
Akimoto Yutaka,
Mifune Hideo,
Shioduka Shinichi,
Hamaguchi Hideo,
Toru Michio,
Shibuya Haruo
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1998.tb03877.x
Subject(s) - taqi , linkage disequilibrium , allele , dopamine receptor d2 , genetics , dopamine receptor , polymorphism (computer science) , dopamine , odds ratio , biology , medicine , gene , receptor , endocrinology , haplotype
Dopamine D2 receptors have been implicated in the biology of alcohol preference. We examined the‐141 C Ins/Del polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) and the DRD2 Taql A polymorphisms in 209 Japanese alcoholics and 152 age‐ and sex‐matched Japanese controls. The Ins allele was significantly increased in the alcoholics, compared with the controls ( p < 0.002, odds ratio = 1.82). The Taql A1 allele tended to be more frequent in the alcoholics than in the controls ( p < 0.04). Linkage disequilibrium between these two polymorphisms was weak (a maximum δ value = 0.13). The ‐141 C Ins/Del polymorphism may affect the vulnerability for alcoholism presumably through different expression of DRD2 in the Japanese.