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A Family‐Based Analysis of the Association of the Dopamine D2 Receptor ( DRD2 ) with Alcoholism
Author(s) -
Edenberg Howard J.,
Foroud Tatiana,
Koller Daniel L.,
Goate Alison,
Rice John,
Eerdewegh Paul,
Reich Theodore,
Cloninger C. Robert,
Nurnberger John I.,
Kowalczuk Maria,
Wu Bo,
Li T.K.,
Conneally P. M.,
Tischfield Jay A.,
Wu William,
Shears Shantia,
Crowe Raymond,
Hesselbrock Victor,
Schuckit Marc,
Porjesz Bernice,
Begleiter Henri
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1998.tb03680.x
Subject(s) - linkage disequilibrium , transmission disequilibrium test , locus (genetics) , allele , disequilibrium , genetic association , genetics , association (psychology) , psychology , medicine , biology , haplotype , genotype , single nucleotide polymorphism , gene , ophthalmology , psychotherapist
The possible association of the DRD2 locus, and in particular the 7aql‐A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family‐based sample. Neither the transmission/disequilibrium test nor the Affected Family‐Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.