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Common Quantitative Trait Loci for Alcohol‐Related Behaviors and CNS Neurotensin Measures: Voluntary Ethanol Consumption
Author(s) -
Gehle Vaughn M.,
Erwin V. Gene
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1998.tb03666.x
Subject(s) - quantitative trait locus , neurotensin , trait , biology , ethanol , phenotype , genetics , alcohol dependence , inbred strain , turnover , neurotensin receptor , medicine , endocrinology , gene , receptor , alcohol , neuropeptide , biochemistry , management , computer science , economics , programming language
The C57BL/6, DBA/2, and recombinant inbred (RI) strains derived from them (B × D RIs) are the most frequently studied mouse strains with regard to genetic regulation of voluntary ethanol consumption (VEC). We have studied VEC in an alternate genetic model provided by the LS × SS RIs. These RI strains exhibit phenotypic extremes in VEC comparable to the C57BL/6 and DBA/2 mice and genotype‐dependent sex differences in drinking behavior. A correlational analysis between various ethanol‐related behaviors suggests genetic independence of VEC from high‐dose neurosensitivity (sleep time), acute ethanol tolerance, hypothermia, and low‐dose locomotor activity. A search for quantitative trait loci identified a number of putative quantitative trait loci (QTL), three of which are identical to those previously reported for 10% ethanol drinking in the B × D RIs. We also find a significant correlation between low‐affinity neurotensin receptor densities (NTRJ in the frontal cortex and VEC, and more common QTL between these two phenotypes than expected by chance. This suggests a role for frontal cortex NTR L in regulating voluntary ethanol intake