Premium
Cognitive Correlates of Single Neuron Activity in Task‐Performing Animals: Application to Ethanol Research
Author(s) -
Givens Bennet,
Williams Joseph,
Gill T. Michael
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1998.tb03613.x
Subject(s) - cognition , neurophysiology , neuroscience , psychology , cognitive neuroscience , set (abstract data type) , elementary cognitive task , working memory , cognitive psychology , computer science , programming language
The deleterious effects of ethanol on cognitive processes result from an interaction between ethanol and the neural structures that are critical for executing those cognitive functions. Results from studies that employ contemporary behavioral neuroscience techniques are beginning to elucidate the neural circuits that underlie specific cognitive processes, and the stage is set for rigorous investigations into the neural basis for ethanol‐induced cognitive impairments. In this article, the application of single neuron recording techniques to the study of the memory and attentional deficits produced by acute exposure to low levels of ethanol are described, with an emphasis on the advantages of combining physiological techniques with operant behavioral procedures in rats. After reviewing background information on the basic neurophysiological and behavioral techniques, empirical results from this laboratory will be used to illustrate how single‐unit analysis can be applied to the study of ethanol‐induced cognitive impairments.