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Effect of Chronic Ethanol Exposure on Myocardial Phosphoinositide Turnover
Author(s) -
Piano Mariann R.,
Schwertz Dorie W.
Publication year - 1997
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1997.tb03828.x
Subject(s) - medicine , inositol , endocrinology , contractility , phospholipase c , phenylephrine , ethanol , cytosol , chemistry , receptor , biochemistry , enzyme , blood pressure
The effect of chronic ethanol consumption (2 months) on atrial contractility and the myocardial phosphoinositide signaling system was examined in rat heart. Two months of ethanol consumption was not associated with changes in heart weight‐to‐body weight ratios; however, developed twitch tension was significantly lower in the ethanol atria compared with the control atria. Cytosolic and membrane‐associated phospholipase C activity in atrial and ventricular tissue was measured and ethanol consumption was only associated with changes in ventricular cytosolic phospholipase C activity. When examining α 1 ‐adrenergic stimulated phosphoinositide turnover in [ 3 H]inositol radiolabeled left atria, no differences in phenylephrine (10 μM)‐stimulated inositol monophosphate, inositol bisphosphate, inositol trisphosphate, and inositol tetrakisphosphate were found between groups before or at various times after the addition of phenylephrine. It is concluded that short‐term ethanol consumption is associated with depressed contractile function, but not the development of hypertrophy or changes in α 1 ‐adrenoreceptor‐stimulated phosphoinositide turnover.