Premium
First‐Pass Metabolism of Ethanol Is Negligible in Rat Gastric Mucosa
Author(s) -
Levitt Michael D.,
Furne Julie,
DeMaster Eugene
Publication year - 1997
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1997.tb03763.x
Subject(s) - gastric mucosa , ethanol , chemistry , first pass effect , metabolism , gastroenterology , medicine , stomach , biochemistry
Controversy exists concerning whether first‐pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [ 14 C]ethanol in body water plus hepatic metabolism could account for [ 14 C]ethanol absorbed from the pylorus‐ligated stomach. Intact [ 14 C]ethanol in systemic body water accounted for 84 ± 1.9% of the [ 14 C]ethanol absorbed from the stomach over a 30‐min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [ 14 C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [ 14 C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.