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Inhibitory Mechanism of Intestinal Ethanol Absorption Induced by High Acetaldehyde Concentrations: Effect of Intestinal Blood Flow and Substance Specificity
Author(s) -
Kinoshita Hiroshi,
Ijiri Iwao,
Ameno Setsuko,
Fuke Chiaki,
Fujisawa Yoshihide,
Ameno Kiyoshi
Publication year - 1996
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1996.tb01084.x
Subject(s) - acetaldehyde , ethanol , chemistry , absorption (acoustics) , blood flow , alcohol , biochemistry , chromatography , medicine , materials science , composite material
This study describes the effects of high blood acetaldehyde concentrations on the intestinal absorption of ethanol and 2‐butanone using an in situ single‐pass perfusion technique on the rat intestine and the colored microsphere method to measure intestinal blood flow. We found that high blood acetaldehyde concentrations inhibit intestinal ethanol absorption in an inverse proportion to peak acetaldehyde concentrations, decrease intestinal blood flow, and inhibit intestinal absorption of 2‐butanone. The decrease of the intestinal blood flow, induced by high blood acetaldehyde concentrations, is a major mechanism inhibiting intestinal ethanol absorption, but other mechanisms are also thought to inhibit absorption. Therefore, inhibition by high acetaldehyde concentrations is not the only factor affecting ethanol absorption.