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Prenatal Ethanol Exposure: Susceptibility to Convulsions and Ethanol's Anticonvulsant Effect in Amygdala‐Kindled Rats
Author(s) -
Kim C. Kwon,
Dalal Suntanu,
Pinel John P. J.,
Weinberg Joanne
Publication year - 1994
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1994.tb01458.x
Subject(s) - kindling , anticonvulsant , clonus , ethanol , convulsion , stimulation , amygdala , seizure threshold , chemistry , epilepsy , endocrinology , anesthesia , medicine , pharmacology , psychology , neuroscience , biochemistry
The present experiments assessed the effects of prenatal ethanol exposure on the susceptibility to convulsions and on the anticonvulsant effect of ethanol using the electrical kindling model of epilepsy in rats. Adult male Sprague‐Dawley rats from prenatal ethanol (E), pair‐fed (PF), and ad libitum‐fed control (C) treatment groups were tested following the implantation of a stimulation electrode in the left amygdala complex. The same rate viete tested in tout consecutive experiments. Both E and PF rats showed a slightly slower rate of kindling than C rats, as measured by convulsion class but not as measured by forelimb clonus duration (experiment 1). However, the groups did not differ significantly in the electrical stimulation threshold for kindled convulsions (experiment 2). Furthermore, prenatal ethanol exposure had no significant effect on the dose‐response curve for ethanol's (0, 0.9, 1.1, 1.3, and 1.5 g/kg, ip) anticonvulsant effect (experiment 3), or on the rate of tolerance development to ethanol's (1.5 g/kg, ip) anticonvulsant effect (experiment 4) on kindled convulsions. Thus, prenatal exposure to ethanol does not appear to have long‐term effects on the susceptibility to convulsions or on the anticonvulsant effect of ethanol in adult male rats in the kindling model as used in the present experiments.