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Alcohol Acceptance, Preference, and Sensitivity in Mice.
Author(s) -
Rodriguez Lawrence A.,
Plomin Robert,
Blizard David A.,
Jones Byron C.,
McClearn Gerald E.
Publication year - 1994
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1994.tb01444.x
Subject(s) - heritability , preference , inbred strain , genetic similarity , genetic correlation , biology , selection (genetic algorithm) , linkage (software) , genetics , genetic variation , psychology , evolutionary biology , statistics , demography , genetic diversity , population , mathematics , gene , computer science , artificial intelligence , sociology
Although the recombinant inbred strain method was designed for molecular genetic analysis of linkage, it also provides powerful quantitative genetic analyses of heritability and genetic correlations. Measures of alcohol acceptance, alcohol preference, and hypnotic dose sensitivity (HDS) were assessed in 21 strains of mice from the BXD Rl series. Sex differences were found to be significant at a phenotypic level. However, heritability estimates for acceptance, preference, and HDS are similar in males and females. Heritability estimates for the three measures are ∼0.20 for acceptance and preference, and 0.10 for HDS. Analyses of genetic correlations reveal that acceptance and preference share some degree of genetic influence, although they mostly operate under different genetically mediated mechanisms. HDS did not show a significant genetic relationship to either acceptance or preference. Strong correlations were obtained when acceptance, preference, and HDS strain means were correlated across male and female recombinant inbreds, suggesting substantial genetic similarity across sexes.