Premium
Effects of Ethanol on the Contractile Function of the Heart: A Review
Author(s) -
Thomas Andrew P.,
Rozanski Dennis J.,
Renard Dominique C.,
Rubin Emanuel
Publication year - 1994
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1994.tb00891.x
Subject(s) - contractility , inotrope , ethanol , cardiac muscle , medicine , cardiomyopathy , cardiac function curve , in vivo , cardiology , myocyte , chemistry , endocrinology , heart failure , biology , biochemistry , microbiology and biotechnology
Chronic ethanol consumption leads to a number of alterations in the contractile function of the heart and is a leading cause of cardiomyopathy. Ethanol also has an acute negative inotropic effect mediated by direct interaction with cardiac muscle cells, although this action is often masked by indirect actions resulting from enhanced release of catecholamines in vivo. This article reviews the effects of ethanol on the contractile function of the heart. The specific targets affected by ethanol in cardiac muscle cells are discussed in terms of potential mechanisms underlying the depressions of contractility resulting from both acute and chronic actions of ethanol.