Premium
The Subchronic Effects of the TRH Analog TA‐0910 and Bromocriptine on Alcohol Preference in Alcohol‐Preferring Rats: Development of Tolerance and Cross‐Tolerance
Author(s) -
Mason George A.,
Rezvani Amir H.,
Grady Danny R.,
Garbutt James C.
Publication year - 1994
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1994.tb00104.x
Subject(s) - bromocriptine , alcohol , cross tolerance , endocrinology , chemistry , medicine , dopamine , agonist , dopamine agonist , ethanol , pharmacology , hormone , biochemistry , receptor , dopaminergic , prolactin , morphine
In a previous study, we showed that a single injection of the thyrotropin‐releasing hormone analog TA‐0910 dose‐dependently reduced alcohol intake in alcohol‐preferring (P) rats and increased their water intake over a 24‐hr period. In the present study, the effects of seven consecutive, once‐daily injections of TA‐0910 (0.75 mg/kg, ip) on alcohol preference were determined. P rats developed tolerance to the attenuating effects of TA‐0910 on alcohol intake within 3–5 days. Following the development of tolerance to TA‐0910, rats were injected with the dopamine agonist bromocriptine (0.5 mg/kg, sc). In the presence of tolerance to TA‐0910, the attenuating effect of bromocriptine on alcohol intake was reduced. When rats were made tolerant to the attenuating effects of bromocriptine, they exhibited tolerance to the attenuating effects of TA‐0910. These findings indicate that tolerance to the effects of TA‐0910 on alcohol intake occurs and suggest dopamine involvement in the mechanism of action of TA‐0910 in reducing alcohol intake in P rats.