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Dopamine D 2 Receptor Gene Expression in Rat Lines Selected for Differences in Voluntary Alcohol Consumption
Author(s) -
Syvälahti E. K. G.,
Pohjalainen T.,
Korpi E. R.,
Pälvimäki E.P.,
Ovaska T.,
Kuoppamäki M.,
Hietala J.
Publication year - 1994
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1994.tb00078.x
Subject(s) - dopamine receptor d2 , nucleus accumbens , dopamine receptor d1 , dopamine receptor , receptor , striatum , dopamine , sch 23390 , medicine , endocrinology , taqi , gene expression , gene , alcohol , chemistry , biology , genetics , allele , biochemistry , polymorphism (computer science)
A selective breeding program has led to the establishment of the alcohol‐preferring AA (Alko, Alcohol) and alcohol‐avoiding ANA (Alko, Nonalcohol) rat lines. To reveal putative baseline differences in dopamine receptor gene expression and dopamine receptor binding profile in the AA and ANA rat lines, we assessed striatal D 2 mRNA levels in these two rat lines. Autoradiographical studies on dopamine D 1 and D 2 receptors in the striatum and nucleus accumbens were also performed with [ 3 H]SCH 23390 and [ 125 I]iodosulpiride/[ 3 H]spiperone, respectively. The baseline differences in D 1 or D 2 receptor binding and D 2 receptor gene expression between AA and ANA rat lines are marginal, and are not likely to play a role in the genetic background of the differential alcohol drinking behavior of these rat lines.