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Alcohol Consumption and Alcohol Pharmacokinetics: Interactions Within the Normal Population
Author(s) -
Whitfield J. B.,
Martin N. G.
Publication year - 1994
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1994.tb00007.x
Subject(s) - alcohol , pharmacokinetics , alcohol consumption , metabolism , alcohol and health , ethanol , ethanol metabolism , population , chemistry , medicine , endocrinology , physiology , biochemistry , environmental health
We have analyzed the interrelationships between habitual alcohol consumption, peak blood alcohol concentration after a standard dose, and rate of alcohol metabolism in a group of 199 male and 213 female twins. Both peak concentration and rate of metabolism are strongly associated with alcohol consumption levels, even in the range of 0‐10 g of alcohol/day. The peak concentration and rate of metabolism were strongly correlated in both men and women; this is not due to their common dependence on alcohol intake nor to experimental error. These results show that the threshold for effects of habitual consumption on alcohol pharmacokinetics is much lower than previously suspected, and that there are factors that reduce preabsorptive or first‐pass metabolism but increase postabsorptive metabolism.