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Chronic Cadmium Exposure Attenuates Ethanol‐Induced Hypoalgesia in the Adult Rat
Author(s) -
Burkey Robert T.,
Nation Jack R.,
Grover Cathy A.,
Bratton Gerald D.
Publication year - 1993
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1993.tb00787.x
Subject(s) - hypoalgesia , cadmium , ethanol , chemistry , saline , zoology , endocrinology , medicine , cadmium acetate , biology , hyperalgesia , nociception , biochemistry , receptor , organic chemistry
Adult male rats were exposed to a diet containing either 100 ppm added cadmium (Cadmium‐Diet), or a control diet containing no added chemicals (Control‐Diet) for 67 days prior to pain reactivity testing using a tail‐flick procedure. Rats were placed in restraining tubes for a 20‐min acclimation period, then baseline tail‐flick latencies in response to a radiant heat source were measured. Subsequently, half the animals from each group were serially injected intraperitoneally with either 0.5, 1.0, 1.5, or 2.0 g/kg body weight of a 20% v/v ethanol solution, and the other half of the animals were injected with an equivalent volume of saline. Tail‐flick latencies were reassessed at 20‐min intervals over the next 2 hr. Results indicated dose‐dependent ethanol‐induced hypoalgesia in the Control‐Diet animals for the two highest doses, but ethanol‐induced hypoalgesia was evident only at the highest dose for the Cadmium‐Diet animals. Further, the magnitude of this hypoaigesic effect was significantly lower for the Cadmium‐Diet animals than the Control‐Diet animals at the 2.0 g/kg dose. Results are discussed in terms of an attenuation of the pharmacological properties of ethanol by cadmium.