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Saccharin Intake Predicts Ethanol Intake in Genetically Heterogeneous Rats as Well as Different Rat Strains
Author(s) -
Overstreet David H.,
KampovPolevoy Alexey B.,
Rezvani Amir H.,
Murrelle Lenn,
Halikas James A.,
Janowsky David S.
Publication year - 1993
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1993.tb00777.x
Subject(s) - saccharin , ethanol , alcohol , chemistry , endocrinology , medicine , biochemistry , biology
Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn‐Hooded (FH), alcohol‐preferring (P) and Maudsley Reactive rats have been reported to drink ethanol voluntarily, whereas the alcohol‐nonpreferring, Maudsley Nonreactive and Flinders Line (FSL and FRL) rats do not. Saccharin and ethanol intakes were highly correlated (r =+0.61) over all strains, with the FH rats drinking the most of both solutions. Correlation coefficients between pairs of drinking versus nondrinking rat strains were even higher. In a second experiment, genetically heterogeneous F2 progeny from cross‐breeding the ethanol‐preferring FH rats with the ethanol‐nonpreferring Flinders Resistant Line (FRL) rats were studied. The results indicated a high positive correlation between saccharin and ethanol intakes (+0.65). These findings suggest that the association between saccharin and ethanol intakes previously reported in rat strains with different preferences for ethanol may have a similar genetic basis.