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Molecular Mechanism of Ethanol Metabolism by Human Brain to Fatty Acid Ethyl Esters
Author(s) -
Bora Puran S.,
Lange Louis G.
Publication year - 1993
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1993.tb00721.x
Subject(s) - ethyl ester , mechanism (biology) , chemistry , metabolism , ethanol , fatty acid , fatty acid metabolism , biochemistry , organic chemistry , philosophy , epistemology
Ethanol metabolism in the human brain has been documented to occur with the formation of fatty acid ethyl esters. These neutral lipids can disorder membranes and interrupt mitochondrial function. Their formation is under the control of three synthases, localized to grey matter and purified to homogeneity. cDNA cloning demonstrates two of these enzymes to be GSH S‐transferases and has enabled initiation of genetic studies of alcohol‐induced CNS injury.