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Effect of Chronic Ethanol on the Septohippocampal System: A Role for Neurotrophic Factors?
Author(s) -
Walker Don W.,
Heaton Marieta B.,
Lee Nancy,
King Michael A.,
Hunter Bruce E.
Publication year - 1993
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1993.tb00719.x
Subject(s) - neurotrophic factors , neurotrophin , downregulation and upregulation , ethanol , neuroscience , brain derived neurotrophic factor , biology , biochemistry , receptor , gene
The mechanisms by which chronic ethanol exposure produces neuronal damage have not been established. Potentially ethanol may reduce normal neurotrophic influences necessary for neuronal survival, growth, and function. We hypothesized that chronic ethanol exposure might produce a decrease in the synthesis, availability, upregulation, delivery, and/or the biological activity of normally occurring neurotrophic factors, or may alter the capacity of target neurons to respond to these factors. The available evidence leading to this hypothesis and supporting data from our laboratory are discussed.