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Audiogenic Seizure Susceptibility and Auditory Brainstem Responses in Rats Prenatally Exposed to Alcohol
Author(s) -
Berman R. F.,
Beare D. J.,
Church M. W.,
Abel E. L.
Publication year - 1992
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1992.tb01406.x
Subject(s) - prenatal alcohol exposure , audiology , auditory brainstem response , prenatal exposure , medicine , alcohol , hearing loss , brainstem , sensorineural hearing loss , anesthesia , pregnancy , gestation , biology , biochemistry , genetics
Rats prenatally exposed to alcohol (0%, 17.5%, or 35% ethanol‐derived calories) were tested for audiogenic seizure susceptibility on one of postnatal days 18 to 23, then retested 5 days later. Prenatal alcohol exposure did not influence audiogenic seizure susceptibility or severity. There was, however, a significant increase in seizure incidence on the retest day for all groups, suggesting a priming effect. Auditory brainstem response (ABR) data suggested that prenatal alcohol exposure and acoustic trauma (i.e., exposure to an alarm bell used for eliciting audiogenic seizures) induced measurable sensorineural hearing loss, and that the combined exposure to alcohol and acoustic trauma interacted additively to produce greater hearing loss than either alone.