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Alcoholism and the D 2 Receptor Gene
Author(s) -
Cook Brian L.,
Wang Zhe Wu,
Crowe Raymond R.,
Hauser Richard,
Freimer Martin
Publication year - 1992
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1992.tb00683.x
Subject(s) - allele , allele frequency , gene , medicine , receptor , association (psychology) , genetics , endocrinology , biology , psychology , psychotherapist
The allelic association of the human dopamine D 2 receptor gene and alcoholism was evaluated in 20 male alcoholics and 20 controls (sex, race, and geographic place of birth matched). This study further examines the issue of alcoholism severity and A1 allele frequency. No difference in A1 allele frequency was observed between these two groups. Similarly, no relationship between alcoholism severity and A1 frequency within the alcoholics was demonstrated.