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Ethanol Inhibits C 6 Cell Growth: Fetal Alcohol Syndrome Model
Author(s) -
Isenberg Keith,
Zhou Xia,
Moore Blake W.
Publication year - 1992
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1992.tb00663.x
Subject(s) - ethanol , fetal alcohol syndrome , fetus , cell growth , cell culture , nervous system , alcohol , cell , central nervous system , fetal growth , medicine , endocrinology , chemistry , biology , pregnancy , biochemistry , neuroscience , genetics
Maternal consumption of ethanol produces a pattern of malformations, including nervous system abnormalities, in the developing fetus, a state called Fetal Alcohol Syndrome. We report the dose‐dependent inhibition by ethanol of the growth of a glioma derived cell line, C 6 cells; the effects occur at ethanol concentrations commonly encountered in the blood during human intoxication. The effects occur with different morphological subtypes of the cell line and do not occur when the cells are exposed to iso‐osmolar concentrations of other chemicals. The results demonstrate that c 6 cells are a model for the study of the effects of ethanol on nervous system cell growth.