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Neuroadaptive Responses to Chronic Ethanol
Author(s) -
Buck Kari J.,
Harris R. Adron
Publication year - 1991
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1991.tb00544.x
Subject(s) - ethanol , nmda receptor , chemistry , microbiology and biotechnology , receptor , ion channel , voltage dependent calcium channel , neuroscience , biochemistry , calcium , biology , organic chemistry
Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA‐activated chloride channels, voltage‐sensitive calcium channels, NMDA‐activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.