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Ro15‐4513 Attenuates the Consumption of Ethanol in Deprived Rats
Author(s) -
June Harry L.,
Lummis Guy H.,
Colker Richard E.,
Moore Timothy O.,
Lewis Michael J.
Publication year - 1991
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1991.tb00538.x
Subject(s) - saccharin , tap water , chemistry , ethanol , water consumption , food science , zoology , endocrinology , medicine , environmental engineering , biology , biochemistry , environmental science
This research investigated the effects of Ro15‐4513 (Ro15), a partial inverse benzodiarepine agonist, on the drinking behavior of 23‐1/2 hr fluid deprived rats. Water‐deprived rats were maintained on a two‐bottle regimen of a saccharin‐ETOH solution along with tap water available for 30 min/day for several days. Following this acclimation period, animals were pretreated with either Ro15 (1.0, 2.5, and 5.0 mg/kg) or Tween‐80 vehicle injections. Pretreatment with Ro15 at all doses tested resulted in a significant reduction of the saccharin‐ETOH solution; however, Ro15 did not alter the rats’ consumption of water. The effects of Ro15 on general fluid consumption was investigated in Experiment 2. Following acclimation to a two‐bottle regimen of a saccharin‐solution and tap water 30 min/day, naive animals were pretreated with Tween‐80 vehicle or Ro15 injections. Ro15 failed to alter saccharin or water consumption. The results of this study support previous reports suggesting that Ro15 attenuates the oral consumption of ETOH; however, this effect does not appear to be due to a general suppression of fluid intake.