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Brain and Liver Dolichol in Chronic Alcoholism: A Necropsy Study
Author(s) -
Kril Jillian J.,
Pullarkat Raju K.,
Pullarkat Premila S.,
Harper Clive G.
Publication year - 1990
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1990.tb01193.x
Subject(s) - dolichol , chronic alcoholism , chronic alcoholic , medicine , alcoholic liver disease , brain disease , alcohol , gastroenterology , disease , biology , cirrhosis , biochemistry , biosynthesis , enzyme
Cerebral gray and white matter and liver dolichol levels were measured in postmortem samples from chronic alcoholics and nonalcoholic controls following recent suggestions that dolichol levels may be used as a marker for alcoholism. No significant differences in brain dolichol were found between the control and alcoholic groups. A significant reduction in the liver dolichol was observed in the alcoholic group. This was most marked in those alcoholics with liver disease.