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Acute Alcohol Infusion Does Not Alter Plasma Gonadotropins or Prolactin in Ovariectomized Rats
Author(s) -
Subramanian Marappa G.,
SavoyMoore Ruth T.,
Bergeski Barbara A.,
Kruger Michael L.,
Abel Ernest L.
Publication year - 1990
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1990.tb00470.x
Subject(s) - ovariectomized rat , prolactin , medicine , endocrinology , luteinizing hormone , hormone , alcohol , follicle stimulating hormone , blood sampling , basal (medicine) , saline , ethanol , chemistry , biochemistry , insulin , organic chemistry
We examined the effects of acute alcohol on basal plasma FSH, LH, and prolactin in ovariectomized rats. Alcohol infusion and blood sampling were done via an indwelling atrial catheter. Blood samples for alcohol and hormone determinations were collected before, and 5 to 120 min after completion of saline (control) or alcohol in saline (experimental) infusion. Plasma follicle‐stimulating hormone, luteinizing hormone, and prolactin were not altered during the 2‐hr period. Peak blood alcohol concentrations achieved following 1.0‐ and 2.0‐ g/kg body weight of alcohol doses were approximately equal to, and twice, the legal human intoxication levels, respectively. Alcohol clearance rates from blood for the two groups were: 130 ± 3 mg/kg/hr for the 1.0‐g/kg body weight group and 151 ± 3 mg/kg/hr for the 2.0‐g/kg body weight group. These results show that acute alcohol does not affect basal gonadotropins and prolactin secretion in ovariectomized rats.