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Xanthine Oxidase Status in Ethanol‐Intoxicated Rat Liver
Author(s) -
Abbondanza Ada,
Battelli Maria Giulia,
Soffritti Morando,
Cessi Carlo
Publication year - 1989
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1989.tb00434.x
Subject(s) - xanthine oxidase , ethanol , xanthine dehydrogenase , chemistry , xanthine , enzyme , ingestion , biochemistry , oxidase test , endocrinology , medicine , pharmacology
The status of xanthine oxidase in ethanol‐induced liver injury has been investigated in the rat, by acute and chronic ethanol treatments. A 38% increase of the enzyme O‐form was observed after repeated ethanol administration. Chronic intoxication caused a significant decrease of total xanthine oxidase activity after both prolonged ethanol feeding and life span ethanol ingestion. The intermediate D/O‐form of xanthine oxidase (that can act either as an oxidase or as a dehydrogenase, being able to react with O 2 as well as with NAD + as electron acceptor 14,16 ) increased 5.5‐fold after prolonged ethanol feeding.